Wanasayansi wamejumuisha nanomaterial iliyo na mali ya antibacterial kwenye nyenzo za kujaza zenye mchanganyiko. Nyenzo hii mpya ya kujaza inaweza kuzuia kutokea tena kwa mashimo ya meno yanayosababishwa na bakteria hatari.
Kuoza jino (inaitwa meno cavities or dental caries) is a very common and widespread bakteria disease in school-going children and adults. Virulent vimelea kama Mutans ya Streptococcus accumulate on the surface of the tooth and start to dissolve hard tissues. Once vimelea settle on the tooth surface, it leads to secondary (or recurrent) tooth decay at the edges of dental kujaza due to production of acid by cavity-causing vimelea which now reside in the interface of dental filling and the tooth. Tooth decay caused by bacteria is responsible for failure of dental restoration material affecting 100 million patients every year. Recurrent tooth cavities and decay leads to tooth extraction and root canal treatments.
Hapo awali, vijazo vya amalgam vinavyojumuisha aloi za chuma vilitumika kwa urejesho wa meno. Ujazo huu ulikuwa na baadhi antibacterial athari lakini pia alikuwa na hasara ya rangi imara, sumu ya zebaki na ukosefu wa kujitoa kwa jino. Sasa resini za mchanganyiko hutumiwa katika vifaa vya kurejesha meno, hata hivyo, hawana mali ya antibacterial ambayo ni drawback kubwa. Pia, kutolewa kwa taratibu kwa mawakala wowote wa mumunyifu kutoka kwa resin huathiri mali zao za mitambo na kusababisha resin ya porous au dhaifu. Nyenzo nyingi za mchanganyiko zilizojaribiwa ni za muda na zinaweza pia kuwa na sumu kwa tishu za jirani hasa kwa vile zinahitaji kipimo cha juu. Vijazo vyenye mchanganyiko wa resini ambavyo vinaonyesha shughuli ya kuzuia bakteria vinaweza kuzuia ukuaji wa magonjwa ya kinywa kama vile kuoza kwa meno.
Katika utafiti uliochapishwa mnamo Mei 28 mnamo Vifaa vya Maandishi na Vifaa vya ACS, researchers describe a new enhanced material having intrinsic potent antibacterial capabilities which can be used for novel dental fillings to prevent recurrent tooth decay. Same team of researchers had discovered in their earlier work that self-assembling building block Fmoc-pentafluro-L-phenylalanine-OH (Fmoc) has potent antibacterial and also anti-inflammatory properties. And, it contains both functional and structural subparts. In the current study, researchers functionally incorporated Fmoc nanoassemblies inside resin-based dental composite material using novel methods developed by them.
The antibacterial capabilities of this new filling material was subsequently evaluated. Researchers also analysed its mechanical strength, optical properties and biocompatibility. When resin-based composites are added with antibacterial nano-assemblies it gets the ability to inhibit and hinder growth and viability of vimelea. The new material was non-toxic and the mechanical or optical properties of the nanaoassemblies remains unaffected by the integration. The antibacterial activity against bacterium S mutans inahitajika kipimo cha chini sana cha nyenzo mpya.
The current study demonstrates antibacterial activity of Fmoc nanoassemblies and its functional incorporation into dental resin composite filling to develop a biocompatible resin composite amalgamated material. The new filling material is pleasant looking, mechanically rigid, has high purity, is inexpensive and can be easily embedded within resin-based filling materials.
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Chanzo (s)
Schnaider, L. et al. 2019. Vifaa Vilivyoboreshwa vya Kuzuia Bakteria-Nanoassembly-Incorporated. Nyenzo na Violesura Vinavyotumika vya ACS. 11 (24). https://doi.org/10.1021/acsami.9b02839
