Jaribio jipya la damu kwa maumivu limetengenezwa ambalo linaweza kusaidia kutoa matibabu ya lengo kulingana na ukali wa maumivu
Daktari anatathmini hali ya mgonjwa maumivu hisia kibinafsi kwa kuwa kwa ujumla huamuliwa na mgonjwa kujiripoti au uchunguzi wa kimatibabu. Sababu kuu ya janga la opioid katika nchi kadhaa ni kuagiza kupita kiasi kwa dawa za kupunguza maumivu na kusababisha uraibu wa dawa hizi. Usajili zaidi hutokea kwa sababu ya kutopatikana kwa mbinu za kupima maumivu kimakosa. Mawasiliano madhubuti ya 'kiwango cha maumivu' hayapatikani kamwe katika mazingira ya kimatibabu hasa kwa watoto na wazee. The maumivu dawa ziliendelea kusajiliwa kwa viwango vyote vya maumivu na hii imezua tatizo kubwa. Maumivu yasiyotibiwa yanaweza kuathiri ubora wa maisha kwa hivyo kupata matibabu maalum ya maumivu ni hitaji la saa.
Kutambua alama za kibayolojia kwa maumivu
Katika utafiti wa mafanikio uliochapishwa katika Nature journal Saikolojia ya Masi, mfano wa kwanza kabisa damu test has been developed by Indiana University School of Medicine, USA which can objectively if not completely quantitively measure severity of a patient’s pain with better accuracy. Researchers enrolled hundreds of participants who were psychiatric patients – a high risk group for pain disorders with increased sensation and perception of pain. Researchers identified gene expression biomarkers in the damu (like a signature or fingerprint which is unique) which could objectively determine severity of one’s pain. These biomarkers were molecules that can reflect severity of a disease, for example glucose in damu is a biomarker for diabetes. Some of the biomarkers like MFAP3 had no previous evidence of being involved in pain while many others were targets of existing drugs.
Kutabiri dawa za asili
Watafiti walitumia uchambuzi wa urejeshaji wa urejeshaji wa dawa za kibayolojia ili kulinganisha alama za kibayolojia za maumivu na dawa zilizopo zisizo za kulevya, dawa na wasifu wa misombo ya asili katika hifadhidata ya maagizo. Uchambuzi ulipendekeza misombo ya risasi inayowezekana ambayo ingerekebisha saini ya maumivu. Misombo hii ilijumuisha dawamfadhaiko pamoja na kiwanja asilia kama Vitamini B6 na Vitamini B12. Michanganyiko iliyoorodheshwa zaidi ilikuwa dawa isiyo ya opioid au kiwanja. Alama za kibayolojia za maumivu zinaweza pia kutabiri wakati mgonjwa angesikia maumivu tena na kuna uwezekano wa kutembelea kliniki. Baadhi ya alama za kibayolojia zilionekana kuwa za ulimwengu wote na zingine zilikuwa mahususi kwa jinsia.
This information from a simple damu test is helpful to evaluate if a patient is suffering from chronic long-term pain. Treatment can be provided objectively and quantifiably especially for headache, fibromyalgia etc. For any therapeutic treatment the goal is to find the right drug which has minimal side effects. This study is a first step towards precision medicine for pain i.e. a personalized tailored treatment and it could change the way pain is treated by medical care.
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Chanzo (s)
Niculescu AB et al 2019. Kuelekea dawa ya usahihi ya maumivu: viambulisho vya uchunguzi wa kibayolojia na dawa zilizotumiwa tena. molecular Psychiatry. https://doi.org/10.1038/s41380-018-0345-5
