Majaribio kwenye seli za panya huonyesha mbinu mpya inayoelekeza kwenye manufaa ya mafuta ya nazi katika kudhibiti Ugonjwa wa Alzheimer
Ugonjwa wa Alzheimer ni ya kimaendeleo ubongo disorder affecting 50 million people worldwide. No cure has been discovered yet for Alzheimers; some forms of treatment available can only relieve symptoms associated with the disease. Alzheimers disease is characterized by hard, insoluble plaque buildup (of amyloid beta proteins) between neurons in the ubongo. This leads to impaired transmission of impulses across neurons and causes symptoms of Alzheimers disease – primarily deterioration of memory. Amyloid beta 40 and Amyloid beta 42 proteins are most abundantly present in the sahani. Beta ya Amyloid protini are dependent on expression of amyloid precursor protein (APP). Research has established the significance of amyloid precursor protein in Alzheimers ugonjwa. Kupungua kwa kiasi kwa shughuli za APP kunaonekana kama tiba ya Alzeima, ingawa utaratibu kamili unaoelezea mkusanyiko wa protini za amiloidi beta bado haujaeleweka kabisa.
Tafiti nyingi huko nyuma zimeonyesha kuwa bikira mafuta ya nazi possibly impacts several pathways which then contributes to progression of Alzheimers disease. Coconut oil constitutes mainly of absorbable medium chain fatty acids metabolized easily by the liver. These fatty acids could also be converted to ketones – considered as an alternate source of energy for neurons. Coconut oil has been shown to have anti-oxidant effects in protecting neurons. These properties make coconut oil a unique dietary fat.
Katika utafiti wa hivi punde uliochapishwa katika Ubongo Utafiti, researchers have investigated the potential effects of coconut oil on the expression of important amyloid precursor protein (APP) which is responsible for amyloid plaque formation. Researchers explored expression of amyloid precursor protein and secretion of amyloid peptides in mammalian cell line Neuro 2A (or N2a) seli which express APP gene. This neural cell line is routinely used to study neuronal differentiation, axonal growth and signaling pathways. In the current study, N2a cells underwent treatment with 0-5 percent concentrations of coconut oil and this led to reduced amyloid precursor protein expression in the cells and also decreased secretion of amyloid peptides 40 and 42. Additionally coconut oil also promoted N2a seli differentiation pointing out that coconut oil has a protecting effect on neuronal cells development.
Matokeo yalionyesha kuwa ADP-Ribosylation Factor 1 (ARF1) - a protini muhimu kwa njia ya siri - kuna uwezekano kuwa inachangia athari za mafuta ya nazi kwenye usemi wa APP na usiri wa peptidi za amiloidi. Ilikuwa wazi kuwa mafuta ya nazi yalifanikisha hili kupitia uwezekano wa mwingiliano na ARF1. ARF1 inajulikana kuwajibika kwa kupanga na kusafirisha protini za koti kwenye seli. Hii ni mara ya kwanza uhusiano kati ya ARF1 na uchakataji wa protini ya amiloidi tangulizi (APP) unaonyeshwa. Muungano huu unadhibitiwa kupitia matibabu ya mafuta ya nazi. Kugonga ARF1 kumepunguza uteaji wa peptidi za amiloidi kuthibitisha jukumu la protini ya ARF1 katika udhibiti wa APP.
Utafiti unaeleza jukumu ambalo halijaripotiwa hapo awali la mafuta ya nazi katika kupunguza usemi wa protini ya amiloidi tangulizi (APP) na usiri wa peptidi za amiloidi, athari iliyopatikana kutokana na udhibiti mdogo wa ARF1. Kwa hivyo, ARF1 inawajibika kwa usafirishaji wa APP ndani ya niuroni ilhali mafuta ya nazi huathiri utendakazi na usemi wa APP. Utafiti huu unafafanua mtazamo mpya kuhusu usafirishaji haramu wa protini ndani ya seli ya amiloidi na hii ni muhimu kuelewa ugonjwa wa Alzeima.
This study suggests that using coconut oil in diet early in one’s life, especially in people genetically predisposed towards Alzheimers disease due to family history, can delay or even stop the onset of the disease. Current and past studies warrant additional investigations and human clinical trials to assess dosage and safety of coconut oil. Coconut oil is inexpensive, is readily available and could be easily incorporated into the diet of at-risk patients.
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{Unaweza kusoma karatasi asili ya utafiti kwa kubofya kiungo cha DOI kilichotolewa hapa chini katika orodha ya (vyanzo) vilivyotajwa}
Chanzo (s)
Bansal A et al 2019. Mafuta ya nazi hupunguza mwonekano wa protini ya amiloidi tangulizi (APP) na utolewaji wa peptidi za amiloidi kwa kuzuiwa kwa kipengele cha 1 cha ADP-ribosylation 1 (ARFXNUMX). Utafiti wa Ubongo. https://doi.org/10.1016/j.brainres.2018.10.001
